Grab pizza, drinks, and grilled favorites at UNO Pizzeria & Grill on Maine Mall Road in South Portland.
UNO Pizzeria & Grill brings a familiar, laid-back energy to 280 Maine Mall Rd in South Portland, where pizza, grill favorites, and bar-side dining meet a steady crowd looking for something satisfying. The atmosphere fits everything from a casual lunch stop to a relaxed dinner after errands at the mall, with a menu built for sharing, snacking, and settling in.
Guests know UNO for its classic pizza-first identity, but the appeal goes beyond that. It is the kind of place where a family table can stretch from grandparents to toddlers, and where returning visitors can settle into a comfortable routine that feels easy from the start. With open daily hours and a late-night Friday and Saturday schedule, it works well for early dinners, evening plans, and takeout when you want something dependable without overthinking it.
The South Portland location keeps the experience grounded and approachable, with a menu that reflects its pizza restaurant, bar and grill, and Italian-American roots. If you want a place where the pace is relaxed and the focus stays on familiar flavors, UNO delivers that classic neighborhood-restaurant feel in a busy retail area.
UNO Pizzeria & Grill serves up a broad mix of pizza, grill items, and casual restaurant favorites that make it easy to build a meal around what you are craving. From a quick bite to a sit-down dinner, the menu is designed for people who want comfort, variety, and a no-rush setting.
As a bar and grill, it also gives guests a place to unwind with food that pairs well with the social side of dining out. It is a practical choice for family meals, group gatherings, and takeout from the Maine Mall area, especially when you want a familiar restaurant with enough range to satisfy different tastes at the table.
The best part is flexibility. Stop in for lunch, plan a dinner, or swing by later in the evening, especially on Fridays and Saturdays when the kitchen stays open until midnight. UNO keeps things simple: solid menu variety, an easygoing setting, and a location that is convenient for South Portland shoppers and locals alike.
Take a look at our space and what we have to offer
Don't just take our word for it - hear from our satisfied customers
It is located at 280 Maine Mall Rd in South Portland.
UNO Pizzeria & Grill is a pizza restaurant, bar and grill, and Italian-American style restaurant with a casual dining feel.
It is open Monday through Thursday from 11:00 AM to 11:00 PM, Friday and Saturday from 11:00 AM to 12:00 AM, and Sunday from 11:00 AM to 11:00 PM.
Yes, it is open 7 days a week.
Yes, online ordering is available through the website link provided.
Expect a casual, familiar restaurant experience with a menu that works well for lunch, dinner, and takeout.
Top of the board by the Doozer Ranking: reviews, ratings, what people wrote, and how many hours a week they are open.
Other places near here, whatever their type.
Everything in South Portland on one board →